Radiation Damage to DNA Plasmids in the Presence of Borocaptates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F22%3A00560654" target="_blank" >RIV/61389005:_____/22:00560654 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21340/22:00359663 RIV/68407700:21230/22:00359663
Result on the web
<a href="https://doi.org/10.1093/rpd/ncac094" target="_blank" >https://doi.org/10.1093/rpd/ncac094</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/rpd/ncac094" target="_blank" >10.1093/rpd/ncac094</a>
Alternative languages
Result language
angličtina
Original language name
Radiation Damage to DNA Plasmids in the Presence of Borocaptates
Original language description
Boron derivatives have great potential in cancer diagnostics and treatment. Borocaptates are used in boron neutron capture therapy and potentially in proton boron fusion therapy. This work examines modulation effects of two borocaptate compounds on radiation-induced DNA damage. Aqueous solutions of pBR322 plasmid containing increasing concentrations of borocaptates were irradiated with Co-60 gamma rays or 30 MeV protons. Induction of single and double DNA strand breaks was investigated using agarose gel electrophoresis. In this model system, representing DNA without the intervention of cellular repair mechanisms, the boron derivatives acted as antioxidants. Clinically relevant boron concentrations of 40 ppm reduced the DNA single strand breakage seven-fold. Possible mechanisms of the observed effect are discussed.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Radiation Protection Dosimetry
ISSN
0144-8420
e-ISSN
1742-3406
Volume of the periodical
198
Issue of the periodical within the volume
9-11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
532-536
UT code for WoS article
000844405700007
EID of the result in the Scopus database
2-s2.0-85146797139