Radium targets for cyclotron production of 225Ac in view of targeted alpha therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F23%3A00579004" target="_blank" >RIV/61389005:_____/23:00579004 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s00259-023-06333-x" target="_blank" >https://doi.org/10.1007/s00259-023-06333-x</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Radium targets for cyclotron production of 225Ac in view of targeted alpha therapy
Original language description
Targeted alpha therapy using the radionuclide Ac-225 has shown remarkable beneft in clinical trials to patients sufering from various cancer types. Currently most Ac-225 is produced from a few sources of Th-229 existing worldwide. However, the total amount available is only sufcient for a few thousand patient doses. Given a projected demand that is several orders of magnitude higher, alternative paths for the production of Ac-225 must be developed. We have been investigating the routenusing the Ra-226(p,2n)Ac-225 reaction. It is particularly attractive due to its large cross-section near 17 MeV proton energy and because it can be readily employed at a large number of cyclotron facilities. The excitation function of this reaction has been previously measured by us for a few energies, but discrepancies with calculations remain. Hence, new irradiation experiments are required to improve the knowledge of the excitation function to support the industrial production of Ac-225 via this route.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů