Polymer conjugated bovine seminal ribonuclease inhibits growth of solid tumors and development of metastases in mice.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F01%3A55010265" target="_blank" >RIV/61389013:_____/01:55010265 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/01:00004372 RIV/00023736:_____/01:00004456

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Polymer conjugated bovine seminal ribonuclease inhibits growth of solid tumors and development of metastases in mice.

Original language description

Bovine seminal ribonuclease exerts a potent cytotoxic activity when administered intratumorally to the nude mice bearing human tumors. Ineffectiveness of intravenous or intraperitoneal administration led us to synthesize polymeric conjugates with BS-RNase to prevent degradation in blood vessels. Hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] was used for BS-RNase modification and PHPMA-BS-RNase conjugates were prepared.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

48

Issue of the periodical within the volume

2

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

127-132

UT code for WoS article

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EID of the result in the Scopus database

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