Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F02%3A55020060" target="_blank" >RIV/61389013:_____/02:55020060 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation.

Original language description

To develop long-circulating gene delivery vectors, the proerties of polyplexes prepared by self assembly of DNA with poly-L-lysine or polyethylenimine, surface-modified with either monovalent polyethylene glycol or multivalent copolymer of N-(2-hydroxypropyl)methacrylamide with methacryloylglycylglycine 4-nitrophenyl ester (PHPMA) were compared. Polymer modification correlate the biophysical properties of the vectors with their distribution following intravenous injection in mice.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

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Project

<a href="/en/project/GV307%2F96%2FK226" target="_blank" >GV307/96/K226: New macromolecular systems for targeted delivery of biological active compounds in the living organism</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Therapy

ISSN

1525-0016

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

463-472

UT code for WoS article

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EID of the result in the Scopus database

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