Structural, dynamic and mechanical properties of POPC at low cholesterol concentration studied in pressure/temperature space.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F03%3A55033330" target="_blank" >RIV/61389013:_____/03:55033330 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Structural, dynamic and mechanical properties of POPC at low cholesterol concentration studied in pressure/temperature space.

Original language description

We have studied the structural, dynamic and mechanical properties of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC)/cholesterol binary mixtures by small-angle X-ray scattering. We derived a value of 19 kJ/mol for the transition enthalpy DeltaH(m) of POPC in excess water). With increasing cholesterol concentration, DeltaH(m) drops to about 7 kJ/mol at 20 mol% cholesterol. Time-resolved pressure-scan and temperature-jump experiments reveal that at low cholesterol content (<5-8 mol%) the fluidity and also the bilayer compressibility increase remarkably. In contrast, at concentrations between 5 and 25 mol% cholesterol the bilayer becomes again more rigid and the lipid bilayer spacing increases about 2 &ANGS. These changes are attributed to the onset of phase separation between liquid disordered and liquid ordered phases.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

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Project

<a href="/en/project/KSK4050111" target="_blank" >KSK4050111: Goal-oriented preparation of chemical compounds with well-defined properties</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Biophysics Journal

ISSN

0175-7571

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

8

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

575-585

UT code for WoS article

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EID of the result in the Scopus database

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