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Oligopeptides as targeting structures in cancer therapy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F05%3A00323162" target="_blank" >RIV/61389013:_____/05:00323162 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Oligopeptides as targeting structures in cancer therapy

  • Original language description

    A laminin derived targeting oligopeptide sequence YESIGVAVS was covalently linked to N-(2-hydroxypropyl)methacrylamide (HPMA) based copolymers. Two peptides derived from gonadotropin releasing hormone (GnRH) were also conjugated to HPMA copolymers and used for modification of adenoviral gene delivery vectors. The influence of the polymer coating with and without the targeting peptide on the expression of reporter genes was investigated.

  • Czech name

    Oligopeptidy jako směrující struktury v nádorové terapii

  • Czech description

    Oligopeptid YESIGVAVS odvozený od lamininu byl kovalentně navázán na kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu (HPMA) Dva peptidy odvozené od gonadotropin uvolňujícího hormonu (GnRH) byly také navázány na HPMA kopolymery a použity pro modifikaci adenovirových vektorů pro dopravu genů. Byl studován vliv polymerního obalu se směrujícími peptidy i bez nich na expresi modelového genu.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CD - Macromolecular chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Controlled Release

  • ISSN

    0168-3659

  • e-ISSN

  • Volume of the periodical

    101

  • Issue of the periodical within the volume

    1-3

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    6

  • Pages from-to

  • UT code for WoS article

    000226086800062

  • EID of the result in the Scopus database