Cholesterol-modified superporous poly(2-hydroxyethyl methacrylate) scaffolds for tissue engineering
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F09%3A00330578" target="_blank" >RIV/61389013:_____/09:00330578 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/09:5289 RIV/68378041:_____/09:00330578
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cholesterol-modified superporous poly(2-hydroxyethyl methacrylate) scaffolds for tissue engineering
Original language description
Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with cholesterol and laminin have been developed to design scaffolds that promote cell?surface interaction. Cholesterol- (P(HEMA?CHLMA)) and laminin-modified (LN?PHEMA) superporous PHEMA scaffolds have been prepared by the bulk radical copolymerization of 2-hydroxyethyl methacrylate (HEMA), cholesterol methacrylate (CHLMA) and the cross-linking agent ethylene imethacrylate in the presence of ammonium oxalate crystals to introduce interconnectedsuperpores in the matrix. Neat PHEMA and laminin-modified PHEMA scaffolds facilitated MSC attachment, but did not support cell spreading and proliferation; the viability of the attached cells decreased with time of cultivation. In contrast, MSCs spread and proliferated on P(HEMA?CHLMA) and LN-P(HEMA?CHLMA) hydrogels.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/KAN200520804" target="_blank" >KAN200520804: Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomaterials
ISSN
0142-9612
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
27
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
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UT code for WoS article
000269330400019
EID of the result in the Scopus database
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