Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F10%3A00348858" target="_blank" >RIV/61389013:_____/10:00348858 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy

Original language description

Using HPMA copolymers as a model drug carrier, and doxorubicin and gemcitabine as model drugs, we here show that long-circulating and passively tumor-targeted polymeric drug carriers interact synergistically with radiotherapy, with radiotherapy improvingthe tumor accumulation of the copolymers, and with the copolymers improving both the efficacy and the toxicity of radiochemotherapy. These findings indicate that ?carrier-based radiochemotherapy holds significant potential for improving the treatment ofadvanced solid malignancies.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EI - Biotechnology and bionics

OECD FORD branch

—

Project

<a href="/en/project/1M0505" target="_blank" >1M0505: Center of targeted therapeutic drugs</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advanced Engineering Materials

ISSN

1438-1656

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

—

UT code for WoS article

000283996400005

EID of the result in the Scopus database

—