Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F12%3A00376432" target="_blank" >RIV/61389013:_____/12:00376432 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/macp.201100632" target="_blank" >http://dx.doi.org/10.1002/macp.201100632</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/macp.201100632" target="_blank" >10.1002/macp.201100632</a>

Result language
angličtina
Original language name
Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors
Original language description
Various biodegradable micellar polymer drug carriers based on N -(2-hydroxypropyl)methacrylamide copolymers and their conjugates with doxorubicin are synthesized. The conjugates are designed to treat solid tumors and subsequently to allow carrier elimination from the body. All copolymers self-assemble in aqueous solution into supramolecular structures with highly hydrophobic cholesterol derivatives in the core and doxorubicin located in the hydrophilic shell. The drug is released quickly from the micelles incubated at pH = 5.0 (modelling the endosomes of tumor cells). Slower release of cholesterol derivatives leading to disintegration of the micelles is observed.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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