Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F12%3A00381219" target="_blank" >RIV/61389013:_____/12:00381219 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/marc.201200254" target="_blank" >http://dx.doi.org/10.1002/marc.201200254</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/marc.201200254" target="_blank" >10.1002/marc.201200254</a>
Alternative languages
Result language
angličtina
Original language name
Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127
Original language description
We synthesized statistical poly(2-isopropyl-2-oxazoline? co ?2-butyl-2-oxazolines) (POXs) that are molecularly dissolved below their cloud point temperature in aqueous milieu and are incorporated into micellar nanoparticles of biocompatible Pluronic F127(F127) after heating their solution above transition temperature, T tr . A functional comonomer 2-(but-3-enyl)-2-oxazoline copolymerized into one of the POXs (polymer E) allows introduction of fenolic moieties and subsequent radionuclide labeling with iodine-125. Self-assembly of the polymer E with F127 leads to formation of radioactive nanoparticles with hydrodynamic diameter 20 nm in aqueous solution by heating to 37° C. The nanoparticles are intended to be used as radioimaging tool in solid tumor diagnostics.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Rapid Communications
ISSN
1022-1336
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
19
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
1683-1689
UT code for WoS article
000309451000009
EID of the result in the Scopus database
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