Characterizing crystal disorder of trospium chloride: a comprehensive, 13C CP/MAS NMR, DSC, FTIR, and XRPD study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00391506" target="_blank" >RIV/61389013:_____/13:00391506 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/13:43895363
Result on the web
<a href="http://dx.doi.org/10.1002/jps.23457" target="_blank" >http://dx.doi.org/10.1002/jps.23457</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jps.23457" target="_blank" >10.1002/jps.23457</a>
Alternative languages
Result language
angličtina
Original language name
Characterizing crystal disorder of trospium chloride: a comprehensive, 13C CP/MAS NMR, DSC, FTIR, and XRPD study
Original language description
Analysis of 13C cross-polarization magic angle spinning (CP/MAS) nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), and X-ray powder diffraction data of trospium chloride (TCl) products crystallized from different mixtures of water?ethanol [?(EtOH) = 0.5?1.0] at various temperatures (0°C, 20°C) and initial concentrations (saturated solution, 30%?50% excess of solvent) revealed extensive structural variability of TCl. Although 13C CP/MAS NMR spectra indicated broad variety of structural phases arising from molecular disorder, temperature-modulated DSC identified presence of two distinct components in the products. FTIR spectra revealed alterations in the hydrogen bonding network (ionic hydrogenbond formation), whereas the X-ray diffraction reflected unchanged unit cell parameters. These results were explained by a two-component character of TCl products in which a dominant polymorphic form is accompanied by partly separated nan
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GPP106%2F11%2FP426" target="_blank" >GPP106/11/P426: Enhancement of bioavailability of insoluble pharmaceutical substances by the action of polymeric matrix</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pharmaceutical Sciences
ISSN
0022-3549
e-ISSN
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Volume of the periodical
102
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
1235-1248
UT code for WoS article
000315723700009
EID of the result in the Scopus database
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