In vivo nanotoxicity testing using the zebrafish embryo assay

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00394403" target="_blank" >RIV/61389013:_____/13:00394403 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/C3TB20528B" target="_blank" >http://dx.doi.org/10.1039/C3TB20528B</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C3TB20528B" target="_blank" >10.1039/C3TB20528B</a>

Result language
angličtina
Original language name
In vivo nanotoxicity testing using the zebrafish embryo assay
Original language description
Nanoparticles are increasingly used for biomedical purposes. Many different diagnostic and therapeutic applications are envisioned for nanoparticles, but there are often also serious concerns regarding their safety. Given the fact that numerous new nanomaterials are being developed every day, and that not much is known about the long-term toxicological impact of exposure to nanoparticles, there is an urgent need to establish efficient methods for nanotoxicity testing. The zebrafish (Danio rerio) embryoassay has recently emerged as an interesting intermediate? method for in vivo nanotoxicity screening, enabling (semi-) high-throughput analyses in a system significantly more complex than cultured cells, but at the same time also less invasive? and lessexpensive than large-scale biocompatibility studies in mice or rats. The zebrafish embryo assay is relatively well-established in the environmental sciences, but has not yet gained wide notice in the nanomedicine field. Using prototypic p
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP301%2F12%2F1254" target="_blank" >GAP301/12/1254: Overcoming Natural and Multidrug Resistance by Tumor-Selective Delivery of ABC Transporter/Bcl-2 Inhibitors or Therapeutic Gene under PEG-3 Promoter</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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