Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00394937" target="_blank" >RIV/61389013:_____/13:00394937 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/13:10192089
Result on the web
<a href="http://dx.doi.org/10.1016/j.bmc.2013.07.038" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2013.07.038</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bmc.2013.07.038" target="_blank" >10.1016/j.bmc.2013.07.038</a>

Result language
angličtina
Original language name
Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates
Original language description
Polymer conjugates of anticancer drugs have shown high potential for assisting in cancer treatments. The pH-labile spacers allow site-specific triggered release of the drugs. We synthesized and characterized model drug conjugates with hydrazide bond-containing poly[N-(2-hydroxypropyl)methacrylamide] differing in the chemical surrounding of the hydrazone bond-containing spacer to find structure?drug release rate relationships. The conjugate selected for further studies shows negligible drug release in apH 7.4 buffer but released 50% of the ellipticinium drug within 24 h in a pH 5.0 phosphate saline buffer. The ellipticinium drug retained the antiproliferative activity of the ellipticine.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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