Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00399466" target="_blank" >RIV/61389013:_____/13:00399466 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.colsurfa.2013.08.056" target="_blank" >http://dx.doi.org/10.1016/j.colsurfa.2013.08.056</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfa.2013.08.056" target="_blank" >10.1016/j.colsurfa.2013.08.056</a>

Result language

angličtina

Original language name

Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward

Original language description

Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (RH) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGAPNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer?solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/GA202%2F09%2F2078" target="_blank" >GA202/09/2078: Bioinspired nanoparticles sensitive to environment stimuli</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Colloids and Surfaces. A - Physicochemical and Engineering Aspects

ISSN

0927-7757

e-ISSN

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Volume of the periodical

436

Issue of the periodical within the volume

5 September

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

1092-1102

UT code for WoS article

000326416900135

EID of the result in the Scopus database

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