Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00425219" target="_blank" >RIV/61389013:_____/14:00425219 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/02652048.2013.814729" target="_blank" >http://dx.doi.org/10.3109/02652048.2013.814729</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/02652048.2013.814729" target="_blank" >10.3109/02652048.2013.814729</a>

Result language
angličtina
Original language name
Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size
Original language description
PLGA (poly d,l-lactic-co-glycolic acid) nanoparticles (NPs) encapsulating magnetite nanoparticles (MNPs) along with a model drug human serum albumin (HSA) were prepared by double emulsion solvent evaporation method. This Part I will focus on size and size distribution of prepared NPs, whereas encapsulation efficiency will be discussed in Part II. It was found that mean hydrodynamic particle size was influenced by five important process variables. To explore their effects, a five-factorial, three-level experimental design and statistical analysis were carried out using STATISTICA software. Effect of process variables on the mean size of nanoparticles was investigated and finally conditions to minimize size of NPs were proposed. GAMS/MINOS software was used for optimization. The mean hydrodynamic size of nanoparticles ranged from 115 to 329?nm depending on the process conditions. Smallest possible mean particle size can be achieved by using low polymer concentration and high dispersion e
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
JB - Sensors, detecting elements, measurement and regulation
OECD FORD branch
—

Project
<a href="/en/project/KAN401220801" target="_blank" >KAN401220801: Nanostructures of Controlled Size and Dimensions</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)