Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00425232" target="_blank" >RIV/61389013:_____/14:00425232 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1021/nl404391r" target="_blank" >http://dx.doi.org/10.1021/nl404391r</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/nl404391r" target="_blank" >10.1021/nl404391r</a>

Result language

angličtina

Original language name

Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines

Original language description

Enhanced permeability and retention (EPR) and the (over-) expression of angiogenesis-related surface receptors are key features of tumor blood vessels. As a consequence, EPR-mediated passive and Arg-Gly-Asp (RGD) and Asn-Gly-Arg (NGR) based active tumortargeting have received considerable attention in the last couple of years. Using several different in vivo and ex vivo optical imaging techniques, we here visualized and quantified the benefit of RGD- and NGR-based vascular vs EPR-mediated passive tumortargeting. This was done using 10 nm sized polymeric nanocarriers, which were either labeled with DY-676 (peptide-modified polymers) or with DY-750 (peptide-free polymers). Upon coinjection into mice bearing both highly leaky CT26 and poorly leaky BxPC3tumors, it was found that vascular targeting did work, resulting in rapid and efficient early binding to tumor blood vessels, but that over time, passive targeting was significantly more efficient, leading to higher overall levels and to

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

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Project

<a href="/en/project/GCP207%2F12%2FJ030" target="_blank" >GCP207/12/J030: STIMULI RESPONSIVE NANOCARRIERS FOR HIGHLY EFFICIENT POLYMER THERAPEUTICS</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nano Letters

ISSN

1530-6984

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

972-981

UT code for WoS article

000331343900088

EID of the result in the Scopus database

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