Exploiting end group functionalization for the design of antifouling bioactive brushes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00428662" target="_blank" >RIV/61389013:_____/14:00428662 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/C4PY00281D" target="_blank" >http://dx.doi.org/10.1039/C4PY00281D</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C4PY00281D" target="_blank" >10.1039/C4PY00281D</a>

Result language

angličtina

Original language name

Exploiting end group functionalization for the design of antifouling bioactive brushes

Original language description

Biologically active surfaces are essential in many applications in the fields of biosensing, bioimplants, and tissue engineering. However, the introduction of bioactive motifs without impairment of their ability to resist non-specific interactions with biological media remains a challenge. Herein, we present a straightforward, facile strategy for the creation of bioactive surfaces based on the end-group biofunctionalization of state-of-the-art polymer brushes via an ultra-fast Diels?Alder ?click reaction. Surface-initiated atom transfer radical polymerization is employed to grow antifouling polymers preserving the end groups. These groups are then further converted to a reactive cyclopentadienyl moiety and exploited for the immobilization of biomolecules on the topmost layer of the brush. The minimal chemical modification of the antifouling polymer brush accounts for the full preservation of the fouling resistance of the surface even after biofunctionalization, which is critical for th

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polymer Chemistry

ISSN

1759-9954

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

13

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

4124-4131

UT code for WoS article

000337097500023

EID of the result in the Scopus database

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