Macroporous 2-hydroxyethyl methacrylate hydrogels of dual porosity for cell cultivation: morphology, swelling, permeability, and mechanical behavior

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00435661" target="_blank" >RIV/61389013:_____/14:00435661 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10965-014-0579-0" target="_blank" >http://dx.doi.org/10.1007/s10965-014-0579-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10965-014-0579-0" target="_blank" >10.1007/s10965-014-0579-0</a>

Result language
angličtina
Original language name
Macroporous 2-hydroxyethyl methacrylate hydrogels of dual porosity for cell cultivation: morphology, swelling, permeability, and mechanical behavior
Original language description
Macroporous hydrogels of dual porosity based on cross-linked poly(2-hydroxyethyl methacrylate) (pHEMA) were prepared, and their swelling, mechanical responses, and hydraulic permeability, as well as cell adhesion and proliferation, were examined on gel-based scaffolds. Large pores on the order of tens and hundreds of microns were generated by adding a solid porogen (fractionated particles of sodium chloride) to the polymerization mixture, which was subsequently washed out of the gel. Small pores on theorder of a few microns were formed by the reaction-induced phase separation mechanism caused by addition of a diluent (1-dodecanol), which is a poor solvent for pHEMA. Morphological studies using light and electron microscopy techniques revealed that thelarge pores were embedded in the pHEMA matrix containing small fused spherical pores. Mechanical behavior of the dual-porosity hydrogels characterized by oscillatory shear measurements revealed that despite very high pore volume, the hyd
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
—

Project
<a href="/en/project/GAP108%2F12%2F1538" target="_blank" >GAP108/12/1538: MICROSTRUCTURED HYDROGELS FOR TISSUE ENGINEERING: VISCOELASTIC RESPONSES OF GELS OF VARIOUS MORHOLOGIES.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)