Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00439963" target="_blank" >RIV/61389013:_____/15:00439963 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.apradiso.2015.01.005" target="_blank" >http://dx.doi.org/10.1016/j.apradiso.2015.01.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apradiso.2015.01.005" target="_blank" >10.1016/j.apradiso.2015.01.005</a>

Result language

angličtina

Original language name

Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications

Original language description

Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer was prepared using two approaches. The direct copolymerization with N-methacryloyl-l-tyrosinamide, as well as end-capping of carboxy-terminated PVCL homopolymer with tyramine, were used. In both cases the product was successfully radiolabeled with 125I. The obtained polymers demonstrate cloud-point temperature (TC) values in the range of 33?35 °C in all the studied solvent systems (water, PBS (pH 7.4) and physiological saline solution). Above the cloud pointtemperature, the molecularly dissolved polymer is macroprecipitated from the solution. The TC values close to the human body temperature of this biocompatible poly(N-vinylcaprolactam) polymer makes it a promising material intended for loc

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Radiation and Isotopes

ISSN

0969-8043

e-ISSN

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Volume of the periodical

98

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

7-12

UT code for WoS article

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EID of the result in the Scopus database

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