Identification of large channels in cationic PEGylated cubosome nanoparticles by synchrotron radiation SAXS and Cryo-TEM imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00443727" target="_blank" >RIV/61389013:_____/15:00443727 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/C5SM00169B" target="_blank" >http://dx.doi.org/10.1039/C5SM00169B</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C5SM00169B" target="_blank" >10.1039/C5SM00169B</a>

Result language

angličtina

Original language name

Identification of large channels in cationic PEGylated cubosome nanoparticles by synchrotron radiation SAXS and Cryo-TEM imaging

Original language description

Extra-large nanochannel formation in the internal structure of cationic cubosome nanoparticles results from the interplay between charge repulsion and steric stabilization of the lipid membrane interfaces and is evidenced by cryogenic transmission electron microscopy (Cryo-TEM) and synchrotron radiation small-angle X-ray scattering (SAXS). The swollen cubic symmetry of the lipid nanoparticles emerges through a shaping transition of onion bilayer vesicle intermediates containing a fusogenic nonlamellar lipid. Cationic amphiphile cubosome particles, thanks to the advantages of their liquid crystalline soft porous nanoarchitecture and capability for multi-drug nanoencapsulation, appear to be of interest for the design of mitochondrial targeting devices inanti-cancer therapies and as siRNA nanocarriers for gene silencing.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

<a href="/en/project/GAP208%2F10%2F1600" target="_blank" >GAP208/10/1600: Polymeric particles and nanostructured materials stabilized by surface active molecules</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Soft Matter

ISSN

1744-683X

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

18

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

3686-3692

UT code for WoS article

000353660000021

EID of the result in the Scopus database

2-s2.0-84929493120