Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00447370" target="_blank" >RIV/61389013:_____/15:00447370 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/15:00447370
Result on the web
<a href="http://dx.doi.org/10.1107/S1399004714027928" target="_blank" >http://dx.doi.org/10.1107/S1399004714027928</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1107/S1399004714027928" target="_blank" >10.1107/S1399004714027928</a>
Alternative languages
Result language
angličtina
Original language name
Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states
Original language description
Human LLT1 is a C-type lectin-like ligand of NKR-P1 (CD161, gene KLRB1), a C-type lectin-like receptor of natural killer cells. Using X-ray diffraction, the first experimental structures of human LLT1 were determined. Four structures of LLT1 under various conditions were determined: monomeric, dimeric deglycosylated after the first N-acetylglucosamine unit in two forms and hexameric with homogeneous GlcNAc(2)Man(5) glycosylation. The dimeric form follows the classical dimerization mode of human CD69. The monomeric form keeps the same fold with the exception of the position of an outer part of the long loop region. The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin-like proteins in the glycosylated form.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Crystallographica Section D-Biological Crystalloghraphy
ISSN
1399-0047
e-ISSN
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Volume of the periodical
71
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
578-591
UT code for WoS article
000351155400016
EID of the result in the Scopus database
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