The synthesis and characterization of the poly[N-vinylpyrrolidone-co-ethylidene-bis-3-(N-vinyl-2-pyrrolidone)] hydrogel matrix for drug delivery to the gastrointestinal tract

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F16%3A00462064" target="_blank" >RIV/61389013:_____/16:00462064 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/masy.201650042" target="_blank" >http://dx.doi.org/10.1002/masy.201650042</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/masy.201650042" target="_blank" >10.1002/masy.201650042</a>

Result language

angličtina

Original language name

The synthesis and characterization of the poly[N-vinylpyrrolidone-co-ethylidene-bis-3-(N-vinyl-2-pyrrolidone)] hydrogel matrix for drug delivery to the gastrointestinal tract

Original language description

Hydrogels based on copolymers of N-vinylpyrrolidone and ethylidene-bis-3-(N-vinyl-2-pyrrolidone) (EBVP) were prepared as polymer matrices for controlled release of high loads of hydrophilic compounds into the gastrointestinal tract. EBVP was synthesized and used as a crosslinking agent for the N-vinylpyrrolidone monomer. The polymerization mixtures, containing 65–80 wt.% of the model pharmacologically active compound, were polymerized to create cylindrical formulations. The release experiments were carried out under conditions corresponding to the digestive tract. Various compositions of hydrogel matrices were tested to reveal the influence of the active compound content and the crosslinking ratio on the release kinetics. Processes such as hydrogel swelling, dissolution and formulation disintegration were evaluated. The results obtained show that the system offers many possibilities to control the drug release to meet various medicinal requirements.

Czech name

—

Czech description

—

Type

D - Article in proceedings

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Macromolecular Symposia. Volume 366, Issue 1

ISBN

—

ISSN

1521-3900

e-ISSN

—

Number of pages

9

Pages from-to

14-22

Publisher name

Wiley - V C H Verlag GmbH & Co. KGaA

Place of publication

Weinheim

Event location

Kathmandu

Event date

Sep 7, 2014

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000383600000003