PCL-PEG graft copolymers with tunable amphiphilicity as efficient drug delivery systems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F16%3A00463742" target="_blank" >RIV/61389013:_____/16:00463742 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/C6TB01841F" target="_blank" >http://dx.doi.org/10.1039/C6TB01841F</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C6TB01841F" target="_blank" >10.1039/C6TB01841F</a>
Alternative languages
Result language
angličtina
Original language name
PCL-PEG graft copolymers with tunable amphiphilicity as efficient drug delivery systems
Original language description
The development of flexible drug delivery systems that can be tuned as a function of the drug to be delivered and of the target disease is crucial in modern medicine. For this aim, novel amphiphilic poly(ε-caprolactone)-g-poly(ethylene glycol) (PCL-g-PEG) copolymers with well-controlled design were synthesized by thiol–yne photochemistry. The grafting density and the copolymer amphiphilicity were easily controlled via the reaction parameters: concentration, reaction time, PEG length and the molar ratio between PCL and PEG or the photoinitiator in the reaction mixture. The self-assembling behavior of the copolymers was studied and a correlation between the composition of PCL-g-PEG and the nanoaggregate diameter sizes (28 to 73 nm) and critical aggregation concentrations (1.1 to 4.3 mg L1) was found. The influence of copolymer amphiphilicity on the drug loading was evaluated with various drugs including anticancer drugs (paclitaxel, ABT-199), drugs to overcome multidrug resistance in cancer cells (curcumin, elacridar), an anti-inflammatory drug (dexamethasone) and an antibacterial drug (clofazimine). Finally, the influence of amphiphilicity on curcumin release and toxicity towards MCF-7 cancer cell lines was studied. The impact of the grafting density, PEG length and the overall EG/CL ratio is discussed in detail. Curcumin loaded PCL-g-PEG with lower EG/CL ratios and shorter PEG chains showed higher toxicity compared to their more hydrophilic counterparts.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Materials Chemistry B
ISSN
2050-750X
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
37
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
6228-6239
UT code for WoS article
000384444800008
EID of the result in the Scopus database
2-s2.0-84988850899