Cytotoxicity of poly(p-phenylenediamine)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00472634" target="_blank" >RIV/61389013:_____/17:00472634 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/17:43875217
Result on the web
<a href="http://dx.doi.org/10.1007/s11696-016-0069-4" target="_blank" >http://dx.doi.org/10.1007/s11696-016-0069-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11696-016-0069-4" target="_blank" >10.1007/s11696-016-0069-4</a>
Alternative languages
Result language
angličtina
Original language name
Cytotoxicity of poly(p-phenylenediamine)
Original language description
Although poly(p-phenylenediamine) is an electric non-conductor, it exhibits, analogously to conducting polymers, redox activity and could, therefore, find applications in biomedicine. In the current work, the cytotoxicity of poly(p-phenylenediamine) polymer powder produced by the chemical oxidation of p-phenylenediamine with ammonium peroxydisulfate in acidic aqueous media has been studied. Primary mouse embryonic fibroblasts were used for this purpose. Interestingly, the standard methods for the determination of polymer cytotoxicity based on international standard EN ISO 10993-5 could not be applied. The reason was the interaction of polymer extracts with MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. On the basis of the evaluation of flow cytometry and micrographs taken by fluorescence microscopy on cells treated with extracts of poly(p-phenylenediamine), it can be concluded that the powder polymer possesses severe cytotoxicity. The results suggest that practical application of the polymer within biomedicine is, at the current state of knowledge, difficult, and modification of the preparation techniques and/or subsequent purification of poly(p-phenylenediamine) is needed.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemical Papers
ISSN
0366-6352
e-ISSN
—
Volume of the periodical
71
Issue of the periodical within the volume
2
Country of publishing house
SK - SLOVAKIA
Number of pages
6
Pages from-to
367-372
UT code for WoS article
000394523000013
EID of the result in the Scopus database
2-s2.0-85003952274