Reductively degradable poly(2-hydroxyethyl methacrylate) hydrogels with oriented porosity for tissue engineering applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00473652" target="_blank" >RIV/61389013:_____/17:00473652 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/17:00473652
Result on the web
<a href="http://dx.doi.org/10.1021/acsami.7b01513" target="_blank" >http://dx.doi.org/10.1021/acsami.7b01513</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.7b01513" target="_blank" >10.1021/acsami.7b01513</a>
Alternative languages
Result language
angličtina
Original language name
Reductively degradable poly(2-hydroxyethyl methacrylate) hydrogels with oriented porosity for tissue engineering applications
Original language description
Degradable poly(2-hydroxyethyl methacrylate) hydrogels were prepared from a linear copolymer (Mw = 49 kDa) of 2-hydroxyethyl methacrylate (HEMA), 2-(acethylthio)ethyl methacrylate (ATEMA), and zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC). The deprotection of ATEMA thiol groups by triethylamine followed by their gentle oxidation with 2,2´-dithiodipyridine resulted in the formation of reductively degradable polymers with disulfide bridges. Finally, a hydrogel 3D structure with an oriented porosity was obtained by gelation of the polymer in the presence of needle-like sodium acetate crystals. The pore diameter and porosity of resulting poly(2-hydroxyethyl methacrylate-co-2-(acethylthio)ethyl methacrylate-co-2-methacryloyloxyethyl phosphorylcholine) [P(HEMA-ATEMA-MPC)] hydrogels varied between 59 and 65 mu m and between 70 and 79.6 vol % according to Hg porosimetry, and complete degradation of these materials was reached in 86 days in 0.33 mmol solution of l-cysteine/L in phosphate buffer. The cross-linked P(HEMA-ATEMA-MPC) hydrogels were evaluated as a possible support for human mesenchymal stem cells (MSCs). No cytotoxicity was found for the un-cross-linked thiol-containing and protected P(HEMA-ATEMA-MPC) chains up to a concentration of 5 and 1 wt % in alpha-minimum essential medium, respectively.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA14-14961S" target="_blank" >GA14-14961S: Spinal cord injury reconstruction using surface-modified biodegradable hydrogels with oriented pores seeded with mesenchymal stem cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Applied Materials and Interfaces
ISSN
1944-8244
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
10544-10553
UT code for WoS article
000398246900027
EID of the result in the Scopus database
2-s2.0-85016489742