Radiolabelled polymeric materials for imaging and treatment of cancer: Quo vadis?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00473653" target="_blank" >RIV/61389013:_____/17:00473653 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/adhm.201601115" target="_blank" >http://dx.doi.org/10.1002/adhm.201601115</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adhm.201601115" target="_blank" >10.1002/adhm.201601115</a>

Result language

angličtina

Original language name

Radiolabelled polymeric materials for imaging and treatment of cancer: Quo vadis?

Original language description

Owing to their tunable blood circulation time and suitable plasma stability, polymer-based nanomaterials hold a great potential for designing and utilising multifunctional nanocarriers for efficient imaging and effective treatment of cancer. When tagged with appropriate radionuclides, they may allow for specific detection (diagnosis) as well as the destruction of tumours (therapy) or even customization of materials, aiming to both diagnosis and therapy (theranostic approach). This review provides an overview of recent developments of radiolabelled polymeric nanomaterials (natural and synthetic polymers) for molecular imaging of cancer, specifically, applying nuclear techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT). Different approaches to radiolabel polymers are evaluated from the methodical radiochemical point of view. This includes new bifunctional chelating agents (BFCAs) for radiometals as well as novel labelling methods. Special emphasis is given to eligible strategies employed to evade the mononuclear phagocytic system (MPS) in view of efficient targeting. The discussion encompasses promising strategies currently employed as well as emerging possibilities in radionuclide-based cancer therapy. Key issues involved in the clinical translation of radiolabelled polymers and future scopes of this intriguing research field are also discussed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advanced Healthcare Materials

ISSN

2192-2640

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

31

Pages from-to

1-31

UT code for WoS article

000399717800005

EID of the result in the Scopus database

2-s2.0-85013367943