Thermodynamic and kinetic analysis of phase separation of temperature-sensitive poly(vinyl methyl ether) in the presence of hydrophobic tert-butyl alcohol

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00476353" target="_blank" >RIV/61389013:_____/17:00476353 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00396-017-4100-2" target="_blank" >http://dx.doi.org/10.1007/s00396-017-4100-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00396-017-4100-2" target="_blank" >10.1007/s00396-017-4100-2</a>

Result language
angličtina
Original language name
Thermodynamic and kinetic analysis of phase separation of temperature-sensitive poly(vinyl methyl ether) in the presence of hydrophobic tert-butyl alcohol
Original language description
NMR and isothermal titration calorimetry (ITC) techniques were chosen to examine interactions in a poly(vinyl methyl ether) (PVME)/tert-butyl alcohol (t-BuOH)/water ternary system. The effects of PVME and t-BuOH concentrations on phase separation temperature were examined. Molecules of t-BuOH additive hydrophobically associate with PVME and decrease the phase separation temperature. Thermodynamic parameters connected with phase separation were calculated from NMR results using an approach based on the van’t Hoff equation. Presence of t-BuOH increases the number of PVME monomeric units in one cooperative domain (where the units undergo phase separation as whole—‘all-or-none’). NMR time-resolved relaxation measurements show very different dynamics of the solvent releasing process for low and high PVME concentrations above phase separation temperature. ITC data show that the presence of t-BuOH restricts water solvation of PVME globules. Presented results on the PVME/t-BuOH/D2O system show that the PVME solution properties are not constant in time. The analysis of measurements (and resulting properties) should always be done while considering strong time-dependent behaviour of PVME solutions.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry

Project
<a href="/en/project/GC15-10527J" target="_blank" >GC15-10527J: Spherical „horse in vacuum“ or applicable micelles? Behavior and shape of nanoparticles – anticancer drug carriers in real blood environment.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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