A tumor-targeted polymer theranostics platform for positron emission tomography and fluorescence imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00476747" target="_blank" >RIV/61389013:_____/17:00476747 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/C7NR03306K" target="_blank" >http://dx.doi.org/10.1039/C7NR03306K</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C7NR03306K" target="_blank" >10.1039/C7NR03306K</a>

Result language

angličtina

Original language name

A tumor-targeted polymer theranostics platform for positron emission tomography and fluorescence imaging

Original language description

Here, we describe a novel polymer platform suitable for efficient diagnostics and potential theranostics based on 89Zr-labeled N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymer conjugates. A set of polymers differing in molecular weight with either low dispersity or high dispersity were designed and synthesized and their biodistribution in vivo was successfully and precisely observed over 72 h. Moreover, the feasibility of two imaging techniques, fluorescence imaging (FI) and positron emission tomography (PET), was compared using labeled polymer conjugates. Both methods gave comparable results thus showing the enhanced diagnostic potential of the prepared polymer–dye or polymer–chelator–89Zr constructs. The in vivo and ex vivo PET/FI studies indicated that the dispersity and molecular weight of the linear HPMA polymers have a significant influence on the pharmacokinetics of the polymer conjugates. The higher molecular weight and narrower distribution of molecular weights of the polymer carriers improve their pharmacokinetic profile for highly prolonged blood circulation and enhanced tumor uptake. Moreover, the same polymer carrier with the anticancer drug doxorubicin bound by a pH-sensitive hydrazone bond showed higher cytotoxicity and cellular uptake in vitro. Therefore, HPMA copolymers with low dispersity and a molecular weight near the limit of renal filtration can be used as highly efficient polymer carriers of tumor-targeted therapeutics or for theranostics with minimal side effects.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nanoscale

ISSN

2040-3364

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

30

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

10906-10918

UT code for WoS article

000406847800041

EID of the result in the Scopus database

2-s2.0-85027070390