Low-thrombogenic fibrin-heparin coating promotes in vitro endothelialization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00478912" target="_blank" >RIV/61389013:_____/17:00478912 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/17:00478912
Result on the web
<a href="http://dx.doi.org/10.1002/jbm.a.36152" target="_blank" >http://dx.doi.org/10.1002/jbm.a.36152</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jbm.a.36152" target="_blank" >10.1002/jbm.a.36152</a>
Alternative languages
Result language
angličtina
Original language name
Low-thrombogenic fibrin-heparin coating promotes in vitro endothelialization
Original language description
Long-term performance of implanted cardiovascular grafts can be ensured if living endothelium overgrows their surface. Surface modifications to implants are therefore being sought that can encourage endothelialization while preventing thrombus formation until the natural endothelium is formed. In the present study, heparin was covalently attached to a fibrin mesh grown from a polyvinyl chloride (PVC) substrate surface by the catalytic action of surface immobilized thrombin on a fibrinogen solution. The coating prevented platelet activation, thrombin generation and clot formation, and reduced inflammatory reactions when exposed to fresh human whole blood circulating in a Chandler loop model. In addition, in vitro seeded human umbilical vein and human saphenous vein endothelial cells showed considerably enhanced attachment and proliferation on the coating.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV15-29153A" target="_blank" >NV15-29153A: Development of an aortic heart valve based on pericardium using primary and stem cells and mechanical loading in a bioreactor</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biomedical Materials Research. Part A
ISSN
1549-3296
e-ISSN
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Volume of the periodical
105
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
2995-3005
UT code for WoS article
000411867800007
EID of the result in the Scopus database
2-s2.0-85026837396