Phthalocyanine-conjugated upconversion NaYF4:Yb3+/Er3+@SiO2 nanospheres for NIR-triggered photodynamic therapy in a tumor mouse model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00483483" target="_blank" >RIV/61389013:_____/17:00483483 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10367201
Result on the web
<a href="http://dx.doi.org/10.1002/cmdc.201700508" target="_blank" >http://dx.doi.org/10.1002/cmdc.201700508</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cmdc.201700508" target="_blank" >10.1002/cmdc.201700508</a>
Alternative languages
Result language
angličtina
Original language name
Phthalocyanine-conjugated upconversion NaYF4:Yb3+/Er3+@SiO2 nanospheres for NIR-triggered photodynamic therapy in a tumor mouse model
Original language description
Photodynamic therapy (PDT) has garnered immense attention as a minimally invasive clinical treatment modality for malignant cancers. However, its low penetration depth and photodamage of living tissues by UV and visible light, which activate a photosensitizer, limit the application of PDT. In this study, monodisperse NaYF4:Yb3+/Er3+ nanospheres 20 nm in diameter, that serve as near-infrared (NIR)-to-visible light converters and activators of a photosensitizer, were synthesized by high-temperature co-precipitation of lanthanide chlorides in a high-boiling organic solvent (octadec-1-ene). The results demonstrate that the NaYF4:Yb3+/Er3+@SiO2-PEI-Pc-PEG nanospheres have great potential as a novel NIR-triggered PDT nanoplatform for deep-tissue cancer therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemMedChem
ISSN
1860-7179
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
Issue 24
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
2066-2073
UT code for WoS article
000418356400008
EID of the result in the Scopus database
2-s2.0-85037361989