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Multiple-level porous polymer monoliths with interconnected cellular topology prepared by combining hard sphere and emulsion templating for use in bone tissue engineering

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00486635" target="_blank" >RIV/61389013:_____/18:00486635 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1002/mabi.201700306" target="_blank" >http://dx.doi.org/10.1002/mabi.201700306</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/mabi.201700306" target="_blank" >10.1002/mabi.201700306</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Multiple-level porous polymer monoliths with interconnected cellular topology prepared by combining hard sphere and emulsion templating for use in bone tissue engineering

  • Original language description

    A combination of hard sphere and high internal phase emulsion templating gives a platform for synthesizing hierarchically porous polymers with a unique topology exhibiting interconnected spherical features on multiple levels. Polymeric spheres are fused by thermal sintering to create a 3D monolithic structure while an emulsion with a high proportion of internal phase and monomers in the continuous phase is added to the voids of the previously constructed monolith. Following polymerization of the emulsion and dissolution of the templating structure, a down-replicating topology is created with a primary level of pores as a result of fused spheres of the 3D monolithic structure, a secondary level of pores resulting from the emulsion's internal phase, and a tertiary level of interconnecting channels. Thiol-ene chemistry with divinyladipate and pentaerythritol tetrakis(3-mercaptopropionate) is used to demonstrate the preparation of a crosslinked polyester with overall porosity close to 90%. Due to multilevel porosity, such materials are interesting for applications in bone tissue engineering, possibly simulating the native sponge like bone structure. Their potential to promote ossteointegration is tested using human bone derived osteoblasts. Material–cell interactions are evaluated and they reveal growth and proliferation of osteoblasts both on surface and in the bulk of the scaffold.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

    <a href="/en/project/LO1507" target="_blank" >LO1507: Polymers for Advanced Technologies and a Better Quality of Life</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Macromolecular Bioscience

  • ISSN

    1616-5187

  • e-ISSN

  • Volume of the periodical

    18

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    8

  • Pages from-to

    1-8

  • UT code for WoS article

    000425026400009

  • EID of the result in the Scopus database

    2-s2.0-85037649510