Poly(ethylene oxide monomethyl ether)-block-poly(propylene succinate) nanoparticles: synthesis and characterization, enzymatic and cellular degradation, micellar solubilization of paclitaxel, and in vitro and in vivo evaluation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00491038" target="_blank" >RIV/61389013:_____/18:00491038 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/18:10377408

Result on the web

<a href="http://dx.doi.org/10.1021/acs.biomac.8b00048" target="_blank" >http://dx.doi.org/10.1021/acs.biomac.8b00048</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.biomac.8b00048" target="_blank" >10.1021/acs.biomac.8b00048</a>

Result language

angličtina

Original language name

Poly(ethylene oxide monomethyl ether)-block-poly(propylene succinate) nanoparticles: synthesis and characterization, enzymatic and cellular degradation, micellar solubilization of paclitaxel, and in vitro and in vivo evaluation

Original language description

Polyester-based nanostructures are widely studied as drug-delivery systems due to their biocompatibility and biodegradability. They are already used in the clinic. In this work, we describe a new and simple biodegradable and biocompatible system as the Food and Drug Administration approved polyesters (poly-ε-caprolactone, polylactic acid, and poly(lactic-co-glycolic acid)) for the delivery of the anticancer drug paclitaxel (PTX) as a model drug. A hydrophobic polyester, poly(propylene succinate) (PPS), was prepared from a nontoxic alcohol (propylene glycol) and monomer from the Krebs’s cycle (succinic acid) in two steps via esterification and melt polycondensation. Furthermore, their amphiphilic block copolyester, poly(ethylene oxide monomethyl ether)-block-poly(propylene succinate) (mPEO-b-PPS), was prepared by three steps via esterification followed by melt polycondensation and the addition of mPEO to the PPS macromolecules. Analysis of the in vitro cellular behavior of the prepared nanoparticle carriers (NPs) (enzymatic degradation, uptake, localization, and fluorescence resonance energy-transfer pair degradation studies) was performed by fluorescence studies. PTX was loaded to the NPs of variable sizes (30, 70, and 150 nm), and their in vitro release was evaluated in different cell models and compared with commercial PTX formulations. The mPEO-b-PPS copolymer analysis displays glass transition temperature < body temperature < melting temperature, lower toxicity (including the toxicity of their degradation products), drug solubilization efficacy, stability against spontaneous hydrolysis during transport in bloodstream, and simultaneous enzymatic degradability after uptake into the cells. The detailed cytotoxicity in vitro and in vivo tumor efficacy studies have shown the superior efficacy of the NPs compared with PTX and PTX commercial formulations.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomacromolecules

ISSN

1525-7797

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

2443-2458

UT code for WoS article

000438470800009

EID of the result in the Scopus database

2-s2.0-85049723626