Optimizing the Cu-RDRP of N-(2-hydroxypropyl) methacrylamide toward biomedical applications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00500627" target="_blank" >RIV/61389013:_____/19:00500627 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2019/PY/C8PY01569D#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2019/PY/C8PY01569D#!divAbstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C8PY01569D" target="_blank" >10.1039/C8PY01569D</a>

Result language
angličtina
Original language name
Optimizing the Cu-RDRP of N-(2-hydroxypropyl) methacrylamide toward biomedical applications
Original language description
Aqueous Cu-RDRP of N-(2-hydroxypropyl) methacrylamide, a monomer with important biomedical applications, was optimized with respect to monomer conversion (82–99%), product dispersity (<1.25), and molecular weight control (up to 100 000). For this purpose, different chlorine-based initiators in conjunction with the CuCl/CuCl2/PMDETA catalytic system were used. The utility of the optimized method in the biomedical field was demonstrated in the preparation of the poly(HPMA)-based copolymeric carrier having the anti-cancer drug doxorubicin conjugated through a pH-sensitive hydrazone linker.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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