Carbon nanotube/iron oxide hybrid particles and their PCL-based 3D composites for potential bone regeneration

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00506304" target="_blank" >RIV/61389013:_____/19:00506304 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/19:00506304

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0928493118337639?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0928493118337639?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.msec.2019.109913" target="_blank" >10.1016/j.msec.2019.109913</a>

Result language

angličtina

Original language name

Carbon nanotube/iron oxide hybrid particles and their PCL-based 3D composites for potential bone regeneration

Original language description

This study describes the preparation, and evaluates the biocompatibility, of hydroxylated multi-walled carbon nanotubes (fCNTs) functionalized with magnetic iron oxide nanoparticles (IONs) creating hybrid nanoparticles. These nanoparticles were used for preparing a composite porous poly(ε-caprolactone) scaffolds for potential utilization in regenerative medicine. Hybrid fCNT/ION nanoparticles were prepared in two mass ratios - 1:1 (H1) and 1:4 (H4). PCL scaffolds were prepared with various concentrations of the nanoparticles with fixed mass either of the whole nanoparticle hybrid or only of the fCNTs. The hybrid particles were evaluated in terms of morphology, composition and magnetic properties. The cytotoxicity of the hybrid nanoparticles and the pure fCNTs was assessed by exposing the SAOS-2 human cell line to colloids with a concentration range from 0.01 to 1 mg/ml. The results indicate a gradual increase in the cytotoxicity effect with increasing concentration. At low concentrations, interestingly, SAOS-2 metabolic activity was stimulated by the presence of IONs. The PCL scaffolds were characterized in terms of the scaffold architecture, the dispersion of the nanoparticles within the polymer matrix, and subsequently in terms of their thermal, mechanical and magnetic properties. A higher ION content was associated with the presence of larger agglomerates of particles. With exception of the scaffold with the highest content of the H4 nanoparticle hybrid, all composites were superparamagnetic. In vitro tests indicate that both components of the hybrid nanoparticles may have a positive impact on the behavior of SAOS-2 cells cultivated on the PCL composite scaffolds. The presence of fCNTs up to 1 wt% improved the cell attachment to the scaffolds, and a content of IONs below 1 wt% increased the cell metabolic activity.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Preparation, modification and characterization of materials by radiation</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Materials Science & Engineering C-Materials for Biological Applications

ISSN

0928-4931

e-ISSN

—

Volume of the periodical

104

Issue of the periodical within the volume

November

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

16

Pages from-to

1-16

UT code for WoS article

000487569300053

EID of the result in the Scopus database

2-s2.0-85068204952