Antibacterial silver-conjugated magnetic nanoparticles: design, synthesis and bactericidal effect
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00507831" target="_blank" >RIV/61389013:_____/19:00507831 - isvavai.cz</a>
Alternative codes found
RIV/67985530:_____/19:00507831
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs11095-019-2680-x" target="_blank" >https://link.springer.com/article/10.1007%2Fs11095-019-2680-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11095-019-2680-x" target="_blank" >10.1007/s11095-019-2680-x</a>
Alternative languages
Result language
angličtina
Original language name
Antibacterial silver-conjugated magnetic nanoparticles: design, synthesis and bactericidal effect
Original language description
The aim was to design and thoroughly characterize monodisperse Fe3O4@SiO2-Ag nanoparticles with strong antibacterial properties, which makes them a candidate for targeting bacterial infections.The monodisperse Fe3O4 nanoparticles were prepared by oleic acid-stabilized thermal decomposition of Fe(III) oleate. The particles were coated with silica shell using a water-in-oil reverse microemulsion, involving hydrolysis and condensation of tetramethyl orthosilicate. Resulting Fe3O4@SiO2 particles were modified by (3-mercaptopropyl)trimethoxysilane to introduce 1.1 mmol SH/g. Finally, the Fe3O4@SiO2-SH nanoparticles were decorated with silver nanoclusters formed by reduction of silver nitrate with NaBH4. The particles were analyzed by FTIR, X-ray photoelectron and atomic absorption spectroscopy, dynamic light scattering and vibrating sample magnetometry. The antibacterial activity of the Fe3O4@SiO2 and Fe3O4@SiO2-Ag nanoparticles was tested against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria cultivated on Luria agar plates or in Luria broth. The superparamagnetic Fe3O4@SiO2-Ag nanoparticles (21 nm in diameter. Saturation magnetization 26 A∙m2/kg) were successfully obtained and characterized. Inhibitory and toxic effects against bacteria were documented by incubation of the Fe3O4@SiO2-Ag nanoparticles with Staphylococcus aureus and Escherichia coli. The combination of magnetic properties together with bactericidal effects is suitable for the disinfection of medical instruments, water purification, food packaging, etc.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA17-04918S" target="_blank" >GA17-04918S: Treating Glioblastoma with surface engineered superparamagnetic iron oxide nanoparticles for efficient conjugation with anticancer drugs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical Research
ISSN
0724-8741
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1-12
UT code for WoS article
000480804200001
EID of the result in the Scopus database
2-s2.0-85070703125