SET‐LRP synthesis of well‐defined light‐responsible block copolymer micelles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00509157" target="_blank" >RIV/61389013:_____/19:00509157 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/macp.201900238" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/macp.201900238</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/macp.201900238" target="_blank" >10.1002/macp.201900238</a>
Alternative languages
Result language
angličtina
Original language name
SET‐LRP synthesis of well‐defined light‐responsible block copolymer micelles
Original language description
Herein, the synthesis of well‐defined light‐sensitive amphiphilic diblock copolymers consisting of UV‐responsive poly(2‐nitrobenzyl acrylate) (PNBA) and hydrophilic poly(ethylene oxide) (PEO) blocks is reported. This is achieved by a single electron transfer living radical polymerization (SET‐LRP) of 2‐nitrobenzyl acrylate monomer initiated by PEO‐containing macroinitiator. Despite several reports on PEO‐b‐PNBA copolymers, this is the first time the PNBA block is synthesized by a controlled radical polymerization leading to the copolymers with low dispersity (Ð = 1.10). In water, the copolymers self‐assemble into well‐defined micelles with a hydrodynamic diameter of 25 nm. Upon irradiation with UV‐light, the PNBA units degrade to hydrophilic poly(acrylate) resulting in disassembly of the micelles. Considering the robustness of the reported synthetic protocol, the prepared polymers represent an interesting platform for the construction of new stimuli‐responsive drug delivery systems.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Chemistry and Physics
ISSN
1022-1352
e-ISSN
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Volume of the periodical
220
Issue of the periodical within the volume
19
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
1-7
UT code for WoS article
000484808700001
EID of the result in the Scopus database
2-s2.0-85071474966