A 2D-Raman correlation spectroscopy study of the interaction of the polymer nanocomposites with carbon nanotubes and human osteoblast-like cells interface
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00523879" target="_blank" >RIV/61389013:_____/20:00523879 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0022286020304609?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022286020304609?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molstruc.2020.128135" target="_blank" >10.1016/j.molstruc.2020.128135</a>
Alternative languages
Result language
angličtina
Original language name
A 2D-Raman correlation spectroscopy study of the interaction of the polymer nanocomposites with carbon nanotubes and human osteoblast-like cells interface
Original language description
The objects of this research were two types of polymer nanocomposites: poly(ε-caprolactone)/multiwalled carbon nanotubes (PCL/MWCNTs) and poly(ε-caprolactone)/functionalized multiwalled carbon nanotubes (PCL/MWCNTs-f) (without and with oxidative treatment of MWCNTs prior to nanocomposite production, respectively). These nanocomposites are promising materials for medical and tissue engineering applications. The cell proliferation test, performed by culturing of osteoblast-like U-2 OS cells line (human bone osteosarcoma epithelial cells) on the surface of tested nanocomposites, confirmed their high biocompatibility. In order to distinguish the nature of cells-material interactions the two-dimensional (2D) Raman correlation spectroscopy technique was used. It revealed more developed changes in the proteins of the cells cultured on the PCL/MWCNTs-f compare to PCL/MWCNTs, as the conformation β of amide I emerged in the asynchronous map of PCL/MWCNTs-f. Moreover, it was confirmed that the functionalization of MWCNTs leads to a different pattern of nanocomposite interaction with cells, for PCL/MWCNTs-f the formed cross-peaks indicate the creation of combined domains of polymer with cell proteins. Whereas for PCL/MWCNTs it was predominantly the nanotubes’ amorphous component D1 that induced the cross-peaks formation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Structure
ISSN
0022-2860
e-ISSN
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Volume of the periodical
1212
Issue of the periodical within the volume
15 July
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
1-10
UT code for WoS article
000529345400006
EID of the result in the Scopus database
2-s2.0-85082864095