PEG-neridronate-modified NaYF4:Gd3+,Yb3+,Tm3+/NaGdF4 core-shell upconverting nanoparticles for bimodal magnetic resonance/optical luminescence imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00543052" target="_blank" >RIV/61389013:_____/21:00543052 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/21:00081192 RIV/00216208:11120/21:43921672 RIV/60461373:22340/21:43922107 RIV/46747885:24530/21:00008890
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsomega.1c01313" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.1c01313</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.1c01313" target="_blank" >10.1021/acsomega.1c01313</a>
Alternative languages
Result language
angličtina
Original language name
PEG-neridronate-modified NaYF4:Gd3+,Yb3+,Tm3+/NaGdF4 core-shell upconverting nanoparticles for bimodal magnetic resonance/optical luminescence imaging
Original language description
Upconverting nanoparticles are attracting extensive interest as a multimodal imaging tool. In this work, we report on the synthesis and characterization of gadolinium-enriched upconverting nanoparticles for bimodal magnetic resonance and optical luminescence imaging. NaYF4:Gd3+,Yb3+,Tm3+ core upconverting nanoparticles were obtained by a thermal coprecipitation of lanthanide oleate precursors in the presence of oleic acid as a stabilizer. With the aim of improving the upconversion emission and increasing the amount of Gd3+ ions on the nanoparticle surface, a 2.5 nm NaGdF4 shell was grown by the epitaxial layer-by-layer strategy, resulting in the 26 nm core–shell nanoparticles. Both core and core–shell nanoparticles were coated with poly(ethylene glycol) (PEG)-neridronate (PEG-Ner) to have stable and well-dispersed upconverting nanoparticles in a biological medium. FTIR spectroscopy and thermogravimetric analysis indicated the presence of ∼20 wt % of PEG-Ner on the nanoparticle surface. The addition of inert NaGdF4 shell resulted in a total 26-fold enhancement of the emission under 980 nm excitation and also affected the T1 and T2 relaxation times. Both r1 and r2 relaxivities of PEG-Ner-modified nanoparticles were much higher compared to those of non-PEGylated particles, thus manifesting their potential as a diagnostic tool for magnetic resonance imaging. Together with the enhanced luminescence efficiency, upconverting nanoparticles might represent an efficient probe for bimodal in vitro and in vivo imaging of cells in regenerative medicine, drug delivery, and/or photodynamic therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA19-00676S" target="_blank" >GA19-00676S: Biocompatible surface-engineered upconversion nanoparticles for cancer therapy</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Omega
ISSN
2470-1343
e-ISSN
2470-1343
Volume of the periodical
6
Issue of the periodical within the volume
22
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
14420-14429
UT code for WoS article
000661452700046
EID of the result in the Scopus database
2-s2.0-85108823448