Enhanced antitumor efficacy through an “AND gate” reactive oxygen-species-dependent pH-responsive nanomedicine approach
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00543740" target="_blank" >RIV/61389013:_____/21:00543740 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10429197
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/adhm.202100304" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adhm.202100304</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adhm.202100304" target="_blank" >10.1002/adhm.202100304</a>
Alternative languages
Result language
angličtina
Original language name
Enhanced antitumor efficacy through an “AND gate” reactive oxygen-species-dependent pH-responsive nanomedicine approach
Original language description
Anticancer drug delivery strategies are designed to take advantage of the differential chemical environment in solid tumors independently, or to high levels of reactive oxygen species (ROS) or to low pH, compared to healthy tissue. Here, the design and thorough characterization of two functionalizable “AND gate” multiresponsive (MR) block amphiphilic copolymers are reported, aimed to take full advantage of the coexistence of two chemical cues—ROS and low pH—present in the tumor microenvironment. The hydrophobic blocks contain masked pH-responsive side chains, which are exposed exclusively in response to ROS. Hence, the hydrophobic polymer side chains will undergo a charge shift in a very relevant pH window present in the extracellular milieu in most solid tumors (pH 5.6–7.2) after demasking by ROS. Doxorubicin (DOX)-loaded nanosized “AND gate” MR polymersomes (MRPs) are fabricated via microfluidic self-assembly. Chemical characterization reveals ROS-dependent pH sensitivity and accelerated DOX release under influence of both ROS and low pH. Treatment of tumor-bearing mice with DOX-loaded nonresponsive and “AND gate” MRPs dramatically decreases cardiac toxicity. The most optimal “AND gate” MRPs outperform free DOX in terms of tumor growth inhibition and survival, shedding light on chemical requirements for successful cancer nanomedicine.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Healthcare Materials
ISSN
2192-2640
e-ISSN
2192-2659
Volume of the periodical
10
Issue of the periodical within the volume
13
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
2100304
UT code for WoS article
000655851100001
EID of the result in the Scopus database
2-s2.0-85106707358