Inorganic nanomaterials as promoters/inhibitors of amyloid fibril formation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00550974" target="_blank" >RIV/61389013:_____/21:00550974 - isvavai.cz</a>
Result on the web
<a href="https://www.wiley.com/en-ie/Biological+Soft+Matter:+Fundamentals,+Properties,+and+Applications-p-9783527343485" target="_blank" >https://www.wiley.com/en-ie/Biological+Soft+Matter:+Fundamentals,+Properties,+and+Applications-p-9783527343485</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Inorganic nanomaterials as promoters/inhibitors of amyloid fibril formation
Original language description
The exposure of the human population to nanoparticles has been increasing. Inorganic nanoparticles easily penetrate the human body, are biologically active, have a large specific surface area and are able to persist in the environment and accumulate there. Many of them are also promoters/inhibitors of amyloid fibril formation. Amyloidoses are very serious diseases that are characterized by amyloid deposition in various organs and tissues causing their dysfunction. This review addresses the influence of inorganic nanoparticles on the process of amyloid fibril formation, which is a popular topic in nanoparticle science because of associated public health concerns. The effect of nanoparticles on amyloid fibril formation is dependent on several parameters such as nanoparticle size, shape and surface chemistry. It was found that the same type of nanoparticle may have different effects on the process of amyloid fibril formation depending on the model system used. They can promote the fibrillation of some model protein systems, but on the other hand, they can inhibit the fibrillation of others. Some nanoparticles can even decompose amyloid fibrils.
Czech name
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Czech description
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Project
<a href="/en/project/LO1507" target="_blank" >LO1507: Polymers for Advanced Technologies and a Better Quality of Life</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Biological Soft Matter: Fundamentals, Properties, and Applications
ISBN
978-3-527-34348-5
Number of pages of the result
34
Pages from-to
195-228
Number of pages of the book
288
Publisher name
Wiley-VCH
Place of publication
Weinheim
UT code for WoS chapter
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