Metal-free synthesis and self-assembly of poly(ethylene glycol) methyl ether-block-poly(.epsilon.-decalactone)-block-poly(methyl methacrylate) triblock terpolymers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00553636" target="_blank" >RIV/61389013:_____/22:00553636 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S001430572100700X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S001430572100700X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2021.110966" target="_blank" >10.1016/j.eurpolymj.2021.110966</a>

Result language

angličtina

Original language name

Metal-free synthesis and self-assembly of poly(ethylene glycol) methyl ether-block-poly(.epsilon.-decalactone)-block-poly(methyl methacrylate) triblock terpolymers

Original language description

Derived from sustainable sources, ε-decalactone (ε-DL) emerges as a renewable alternative to synthetic cyclic esters. However, its copolymerization with different monomers often requires using metal complexes potentially toxic to humans and the environment. Here, we report the synthesis and self-assembly of poly(ethylene glycol) methyl ether-block-poly(ε-decalactone)-block-poly(methyl methacrylate) (mPEG-block-PDL-block-PMMA) triblock terpolymers via two synthetic pathways using a simple phosphazene- or phosphate-based metal-free catalytic system. Our size exclusion chromatography (SEC) results showed that the two-step synthetic mechanism combining bis(4-nitrophenyl) phosphate (BNPP) and 1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)-phosphoranylidenamino]-2λ5,4λ5-catenadi(phosphazene) (t-BuP4) provided a better polymerization control than sequential copolymerization. In addition, our SAXS and AFM analysis also demonstrated that the blocks are incompatible in the terpolymers, further promoting their self-assembly into multicompartment micelles in water, as confirmed by cryo-TEM. Therefore, mPEG-block-PDL-block-PMMA triblock terpolymers may be used as both environmentally friendly alternatives to metal-catalyzed polymers and drug delivery systems.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Polymer Journal

ISSN

0014-3057

e-ISSN

1873-1945

Volume of the periodical

166

Issue of the periodical within the volume

5 March

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

110966

UT code for WoS article

000783242300001

EID of the result in the Scopus database

2-s2.0-85123959252