Incorporation of fibrin, platelets, and red blood cells into a coronary thrombus in time and space

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00554916" target="_blank" >RIV/61389013:_____/22:00554916 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/22:00013291 RIV/61383082:_____/22:00001194 RIV/00064173:_____/22:43922610 RIV/00216208:11110/22:10434387 RIV/00216208:11120/22:43922610

Result on the web

<a href="https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0041-1739193" target="_blank" >https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0041-1739193</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0041-1739193" target="_blank" >10.1055/s-0041-1739193</a>

Result language

angličtina

Original language name

Incorporation of fibrin, platelets, and red blood cells into a coronary thrombus in time and space

Original language description

We describe the internal structure, spatial organization and dynamic formation of coronary artery thrombi from ST-segment elevation myocardial infarction patients. Scanning electron microscopy (SEM) revealed significant differences among four groups of patients (<2 hours, 2–6 hours, 6–12 hours, and >12 hours) related to the time of ischemia. Coronary artery thrombi from patients presenting less than 2 hours after the infarction were almost entirely composed of platelets, with small amounts of fibrin and red blood cells. In contrast, thrombi from late presenters (>12 hours) consisted of mainly platelets at the distal end, where clotting was initiated, with almost no platelets at the proximal end, while the red blood cell content went from low at the initiating end to more than 90% at the proximal end. Furthermore, fibrin was present mainly on the outside of the thrombi and older thrombi contained thicker fibers. The red blood cells in late thrombi were compressed to a close-packed, tessellated array of polyhedral structures, called polyhedrocytes. Moreover, there was redistribution from the originally homogeneous composition to fibrin and platelets to the outside, with polyhedrocytes on the interior. The presence of polyhedrocytes and the redistribution of components are signs of in vivo clot contraction (or retraction). These results suggest why later thrombi are resistant to fibrinolytic agents and other treatment modalities, since the close-packed polyhedrocytes form a nearly impermeable seal. Furthermore, it is of particular clinical significance that these findings suggest specific disparate therapies that will be most effective at different stages of thrombus development.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30205 - Hematology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Thrombosis and Haemostasis

ISSN

0340-6245

e-ISSN

2567-689X

Volume of the periodical

122

Issue of the periodical within the volume

3

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

434-444

UT code for WoS article

000718575700002

EID of the result in the Scopus database

2-s2.0-85119970139