Stimuli-responsive vitamin E-based micelles: effective drug carriers with a controlled anticancer drug release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00557850" target="_blank" >RIV/61389013:_____/22:00557850 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S003238612200489X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S003238612200489X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.polymer.2022.125001" target="_blank" >10.1016/j.polymer.2022.125001</a>
Alternative languages
Result language
angličtina
Original language name
Stimuli-responsive vitamin E-based micelles: effective drug carriers with a controlled anticancer drug release
Original language description
Herein, a series of vitamin E-based TPGS-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(3-vinyl benzaldehyde) block copolymer micelles were synthesized via reversible addition−fragmentation chain-transfer polymerization (RAFT). d-α-tocopheryl poly(ethylene glycol) 1000 succinate (TPGS) is a good candidate to overcome the big problem of multidrug resistance in cancer therapy because TPGS can inhibit permeability of glycoprotein (P-gp) resulting in restored sensitivity to chemotherapeutics. Doxorubicin (DOX) was loaded within the micelles, as an anticancer model drug, via hydrolytic amide linkage in the hydrophobic block. The DOX-loaded micelles demonstrated high potential as anticancer drug delivery systems through the release of the drug under acidic conditions, varying from pH 7.4 to 5.0. Three different micelles compositions were investigated with various ratios of hydrophilic and hydrophobic blocks (1:1, 4:3, and 4:1). The DOX-conjugated polymer with the shortest hydrophobic segment (4:1), TPGS-poly(2-(dimethylamino)ethyl methacrylate)125-b-poly(3-vinyl benzaldehyde)91, demonstrated excellent in vitro cytotoxicity with pH-responsive characteristics in comparison to free DOX. Although the higher degree of polymerization of the hydrophobic block promoted the drug loading efficiency of the micelles these compositions demonstrated lower cytotoxicity to the A549 cell line of human lung adenocarcinoma. It was concluded that the prepared pH-responsive micelles based on TPGS are promising drug carriers for anticancer drug delivery systems and could be considered to provide multi-drug resistance cancer treatments after further in vitro biological studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymer
ISSN
0032-3861
e-ISSN
1873-2291
Volume of the periodical
253
Issue of the periodical within the volume
22 June
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
125001
UT code for WoS article
000812995700001
EID of the result in the Scopus database
2-s2.0-85131410014