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Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00564362" target="_blank" >RIV/61389013:_____/23:00564362 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/23:00564362 RIV/00216224:14310/23:00130761 RIV/00216208:11110/23:10452074 RIV/00064165:_____/23:10452074

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0168365922007726?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0168365922007726?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jconrel.2022.11.027" target="_blank" >10.1016/j.jconrel.2022.11.027</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis

  • Original language description

    Chronic inflammatory diseases such as rheumatoid arthritis represent a substantial socio-economic impact and have a high prevalence in the modern world. Nano-sized polymer therapeutics have shown suitable characteristics for becoming the next generation of anti-inflammatory nanomedicines. Here, we present biocompatible and stimuli-sensitive N-(2-hydroxypropyl)methacrylamide based polymer conjugates with the anti-inflammatory drug dexamethasone (DEX), which has been tailored for prolonged blood circulation, enhanced inflammatory site accumulation, site-specific drug release and subsequent elimination of the carrier via urine excretion. The hydrodynamic size of novel polymer-DEX nanomedicine was adjusted to prolong its blood circulation whilst maintaining the renal excretability of the polymer carrier after drug release in inflamed tissue. The therapeutic efficacy of the studied polymer nanomedicines was evaluated in a model of dissipated chronic arthritis, i.e. collagen II-induced arthritis, in mice. The pH-sensitive drug attachment enabled enhanced blood circulation with minimal systemic drug release, as well as rapid drug activation in affected joints. Importantly, unlike free DEX, the polymer nanomedicines were able to diminish joint inflammation and arthritis-induced bone damage - even at a reduced dosing regimen - as evaluated by micro computed tomography (micro-CT).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Controlled Release

  • ISSN

    0168-3659

  • e-ISSN

    1873-4995

  • Volume of the periodical

    353

  • Issue of the periodical within the volume

    January

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    12

  • Pages from-to

    30-41

  • UT code for WoS article

    000898783400002

  • EID of the result in the Scopus database

    2-s2.0-85142324204