Meta-isobutoxy phenylboronic acid for nanoscale multi-stimuli-responsive low-molecular-weight hydrogelator
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00575363" target="_blank" >RIV/61389013:_____/23:00575363 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10470954
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsanm.3c03259" target="_blank" >https://pubs.acs.org/doi/10.1021/acsanm.3c03259</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsanm.3c03259" target="_blank" >10.1021/acsanm.3c03259</a>
Alternative languages
Result language
angličtina
Original language name
Meta-isobutoxy phenylboronic acid for nanoscale multi-stimuli-responsive low-molecular-weight hydrogelator
Original language description
Hydrogelators generate hydrogels when dissolved in water, forming a network of interlocking chains on the nanoscale level. For their unique viscoelastic, mechanical, and swelling properties, these hydrogels have found various applications, such as water absorbent, biocompatible, and biodegradable scaffolds in tissue engineering and nanocarriers in drug delivery. When measuring the solubility of p-, m-, and o-isobutoxy derivatives of phenylboronic acid, we identified m-isobutoxyphenylboronic acid (PBA) as a low-molecular-weight hydrogelator, the first of which solely based on phenylboronic acid. At low concentrations, PBA gelated water into a network of cross-linked nanofibers combining amorphous and crystalline phases, as shown by electron and optical microscopy, rheometry, and differential scanning calorimetry and confirmed by small- and wide-angle X-ray scattering. By increasing the PBA concentration, we were able to tailor the elastic modulus (G′) of PBA hydrogels across 2 orders of magnitude, from 2.5 to 103 kPa. In turn, at a specific PBA concentration, we tuned their viscoelastic properties by adding urea, thereby adjusting the gelation temperature between 62 and 56 °C and G′ at body temperature between 63.4 and 30.4 kPa. Moreover, PBA hydrogels dissolved in response to various triggers (pH increase, H2O2 and cyclodextrin addition) and selectively absorbed dyes for liquid mixture separation. These findings demonstrate that PBA has a high potential as a biodegradable, multistimuli-responsive, low-molecular-weight hydrogelator for bioapplications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Applied Nano Materials
ISSN
2574-0970
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
17
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
16055-16064
UT code for WoS article
001051309700001
EID of the result in the Scopus database
2-s2.0-85169021306