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Meta-isobutoxy phenylboronic acid for nanoscale multi-stimuli-responsive low-molecular-weight hydrogelator

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00575363" target="_blank" >RIV/61389013:_____/23:00575363 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/23:10470954

  • Result on the web

    <a href="https://pubs.acs.org/doi/10.1021/acsanm.3c03259" target="_blank" >https://pubs.acs.org/doi/10.1021/acsanm.3c03259</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1021/acsanm.3c03259" target="_blank" >10.1021/acsanm.3c03259</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Meta-isobutoxy phenylboronic acid for nanoscale multi-stimuli-responsive low-molecular-weight hydrogelator

  • Original language description

    Hydrogelators generate hydrogels when dissolved in water, forming a network of interlocking chains on the nanoscale level. For their unique viscoelastic, mechanical, and swelling properties, these hydrogels have found various applications, such as water absorbent, biocompatible, and biodegradable scaffolds in tissue engineering and nanocarriers in drug delivery. When measuring the solubility of p-, m-, and o-isobutoxy derivatives of phenylboronic acid, we identified m-isobutoxyphenylboronic acid (PBA) as a low-molecular-weight hydrogelator, the first of which solely based on phenylboronic acid. At low concentrations, PBA gelated water into a network of cross-linked nanofibers combining amorphous and crystalline phases, as shown by electron and optical microscopy, rheometry, and differential scanning calorimetry and confirmed by small- and wide-angle X-ray scattering. By increasing the PBA concentration, we were able to tailor the elastic modulus (G′) of PBA hydrogels across 2 orders of magnitude, from 2.5 to 103 kPa. In turn, at a specific PBA concentration, we tuned their viscoelastic properties by adding urea, thereby adjusting the gelation temperature between 62 and 56 °C and G′ at body temperature between 63.4 and 30.4 kPa. Moreover, PBA hydrogels dissolved in response to various triggers (pH increase, H2O2 and cyclodextrin addition) and selectively absorbed dyes for liquid mixture separation. These findings demonstrate that PBA has a high potential as a biodegradable, multistimuli-responsive, low-molecular-weight hydrogelator for bioapplications.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ACS Applied Nano Materials

  • ISSN

    2574-0970

  • e-ISSN

  • Volume of the periodical

    6

  • Issue of the periodical within the volume

    17

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    16055-16064

  • UT code for WoS article

    001051309700001

  • EID of the result in the Scopus database

    2-s2.0-85169021306