A smart nanopaper sensor for optical diagnosis of Helicobacter pylori infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00576773" target="_blank" >RIV/61389013:_____/23:00576773 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2023/MA/D3MA00612C" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2023/MA/D3MA00612C</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D3MA00612C" target="_blank" >10.1039/D3MA00612C</a>
Alternative languages
Result language
angličtina
Original language name
A smart nanopaper sensor for optical diagnosis of Helicobacter pylori infection
Original language description
Despite a decline in its prevalence, Helicobacter pylori (H. pylori), as the most common causative agent of chronic gastrointestinal diseases, still infects more than half of the world's population. Although effective, current H. pylori infection diagnostic approaches entail some drawbacks and hurdles, including requiring endoscopy and multiple biopsies, harmful chemicals, and expensive and bulky apparatus. Herein, to tackle some of state-of-the-art limitations, we have developed a biocompatible nanosensor for diagnosis of H. pylori infection. The developed optical sensor comprises NaYF4:Yb,Er,Lu@PEG-NH2 upconversion nanoparticles, red cabbage-extracted anthocyanins, and iron oxide nanoparticles embedded within chitin nanopaper. The enzymatic reaction of H. pylori urease enzyme with urea, which leads to pH changes, and consequently changes in the pH-dependent fluorescence/color profile of the developed sensor via an inner filter effect mechanism, was utilized as a sensing strategy for H. pylori infection diagnosis. A portable 3D-printed smartphone-based imaging platform was also fabricated for monitoring the developed sensor. We believe that our developed smart nanosensor can not only potentially be exploited as an ingestible sensor for non-invasive diagnosis of H. pylori infection, its therapeutic monitoring, and gastrointestinal pH monitoring, but also provide fresh insights into the development of a variety of innovative ingestible/swallowable sensors for non-invasive gastrointestinal diagnostics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA21-04420S" target="_blank" >GA21-04420S: Protective coatings against dissolution/disintegration of upconverting lanthanide-based nanoparticles in biological media</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Materials Advances
ISSN
2633-5409
e-ISSN
2633-5409
Volume of the periodical
4
Issue of the periodical within the volume
20
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
4965-4974
UT code for WoS article
001078532400001
EID of the result in the Scopus database
2-s2.0-85175092366