Highly hydrophilic methacrylamide-based copolymers as precursors for polymeric nanomedicines containing anthracyclines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00580623" target="_blank" >RIV/61389013:_____/24:00580623 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10479667 RIV/60461373:22310/24:43928992
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S001430572400017X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S001430572400017X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eurpolymj.2024.112756" target="_blank" >10.1016/j.eurpolymj.2024.112756</a>
Alternative languages
Result language
angličtina
Original language name
Highly hydrophilic methacrylamide-based copolymers as precursors for polymeric nanomedicines containing anthracyclines
Original language description
The crucial limitation of most low molecular weight cytostatic drugs, including anthracyclines, is their nonspecific biodistribution causing severe adverse effects during cancer treatment. Recently, nanomedicines such as polymer-based systems have been developed as advanced drug delivery systems. Herein, we report the design, synthesis, and characterization of highly water-soluble polymer-carriers based on N‑(1,3‑dihydroxyprop-2-yl)methacrylamide (DHPMA). Polymers differing in molecular weight, hydrodynamic size, and dispersity were synthesized via free or controlled radical polymerization and conjugated to an anthracycline drug pirarubicin (THP) via a pH-sensitive hydrazone bond achieving up to 21 wt% of THP. The DHPMA copolymers were extensively compared to the well-known drug delivery vectors, N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymers. Importantly, DHPMA-based conjugates showed excellent hydrophilicity exceeding that of HPMA-based copolymers and did not aggregate even after loading with THP reaching 21 wt%. The DHPMA-based polymer nanomedicines exhibited excellent cytotoxicity, body biodistribution, tumor accumulation, and antitumor efficacy, significantly reducing the side effects and toxicity comparable to HPMA-based systems, thus demonstrating their applicability and suitability as efficient drug carriers.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Polymer Journal
ISSN
0014-3057
e-ISSN
1873-1945
Volume of the periodical
205
Issue of the periodical within the volume
7 February
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
112756
UT code for WoS article
001159005300001
EID of the result in the Scopus database
2-s2.0-85182421277