Exploring the application of poly(1,2-ethanediol citrate)/polylactide nonwovens in cell culturing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00584926" target="_blank" >RIV/61389013:_____/24:00584926 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fbioe.2024.1332290/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fbioe.2024.1332290/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fbioe.2024.1332290" target="_blank" >10.3389/fbioe.2024.1332290</a>

Result language

angličtina

Original language name

Exploring the application of poly(1,2-ethanediol citrate)/polylactide nonwovens in cell culturing

Original language description

Biomaterials containing citric acid as a building unit show potential for use as blood vessel and skin tissue substitutes. The success in commercializing implants containing a polymer matrix of poly(1,8-octanediol citrate) provides a rationale for exploring polycitrates based on other diols. Changing the aliphatic chain length of the diol allows functional design strategies to control the implant’s mechanical properties, degradation profile and surface energy. In the present work, poly(1,2-ethanediol citrate) was synthesized and used as an additive to polylactide in the electrospinning process. It was established that the content of polycitrate greatly influences the nonwovens’ properties: an equal mass ratio of polymers resulted in the best morphology. The obtained nonwovens were characterized by surface hydrophilicity, tensile strength, and thermal properties. L929 cell cultures were carried out on their surface. The materials were found to be non-cytotoxic and the degree of porosity was suitable for cell colonization. On the basis of the most important parameters for assessing the condition of cultured cells (cell density and viability, cell metabolic activity and lactate dehydrogenase activity), the potential of PLLA + PECit nonwovens for application in tissue engineering was established.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Bioengineering and Biotechnology

ISSN

2296-4185

e-ISSN

2296-4185

Volume of the periodical

12

Issue of the periodical within the volume

15 March

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

1332290

UT code for WoS article

001193121500001

EID of the result in the Scopus database

2-s2.0-85188844655