Charge regulation triggers condensation of short oligopeptides to polyelectrolytes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00586217" target="_blank" >RIV/61389013:_____/24:00586217 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/24:10481334

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/jacsau.3c00668" target="_blank" >https://pubs.acs.org/doi/10.1021/jacsau.3c00668</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/jacsau.3c00668" target="_blank" >10.1021/jacsau.3c00668</a>

Result language

angličtina

Original language name

Charge regulation triggers condensation of short oligopeptides to polyelectrolytes

Original language description

Electrostatic interactions between charged macromolecules are ubiquitous in biological systems, and they are important also in materials design. Attraction between oppositely charged molecules is often interpreted as if the molecules had a fixed charge, which is not affected by their interaction. Less commonly, charge regulation is invoked to interpret such interactions, i.e., a change of the charge state in response to a change of the local environment. Although some theoretical and simulation studies suggest that charge regulation plays an important role in intermolecular interactions, experimental evidence supporting such a view is very scarce. In the current study, we used a model system, composed of a long polyanion interacting with cationic oligolysines, containing up to 8 lysine residues. We showed using both simulations and experiments that while these lysines are only weakly charged in the absence of the polyanion, they charge up and condense on the polycations if the pH is close to the pKa of the lysine side chains. We show that the lysines coexist in two distinct populations within the same solution: (1) practically nonionized and free in solution, (2) highly ionized and condensed on the polyanion. Using this model system, we demonstrate under what conditions charge regulation plays a significant role in the interactions of oppositely charged macromolecules and generalize our findings beyond the specific system used here.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JACS Au

ISSN

2691-3704

e-ISSN

2691-3704

Volume of the periodical

4

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

1775-1785

UT code for WoS article

001184783100001

EID of the result in the Scopus database

2-s2.0-85187657395