Polyvinylpyrrolidone-functionalized graphene oxide as a nanocarrier for dual-drug delivery of quercetin and curcumin against HeLa cancer cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00598047" target="_blank" >RIV/61389013:_____/24:00598047 - isvavai.cz</a>

Result on the web

<a href="https://4spepublications.onlinelibrary.wiley.com/doi/10.1002/vnl.22115" target="_blank" >https://4spepublications.onlinelibrary.wiley.com/doi/10.1002/vnl.22115</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/vnl.22115" target="_blank" >10.1002/vnl.22115</a>

Result language

angličtina

Original language name

Polyvinylpyrrolidone-functionalized graphene oxide as a nanocarrier for dual-drug delivery of quercetin and curcumin against HeLa cancer cells

Original language description

This study is to develop a nanocarrier based on polyvinylpyrrolidone (PVP)-functionalized graphene oxide (GO–PVP), loaded with both curcumin (CUR) and quercetin (QSR), and then its performance compared with nanocarriers carrying the drugs separately. The study also aimed to investigate the cytotoxic effects of these nanocarriers on HeLa cancer cells. To achieve this, GO was synthesized using a modified version of Hummer's method and subsequently functionalized with PVP. Drug loading onto the GO and GO–PVP nanocarriers was achieved through hydrophobic interactions. Furthermore, the ability of the nanocarriers to accommodate a single drug or a combination of drugs was examined. In our study, combined system shows higher drug loading, that is, 28.1% of QSR and 24.34% of CUR onto GO–PVP–QSR–CUR nanocarrier in comparison to single drug nanocarrier systems GO–PVP–QSR and GO–PVP–CUR which loaded 22.5% of QSR and 18.73% of CUR, respectively. Notably, the synthesized nanocarrier exhibited a pH-sensitive drug release pattern. These results collectively suggest that GO–PVP–CUR–QSR displayed significantly higher cytotoxicity against HeLa cancer cells compared to both single-drug nanocarrier systems at the specified concentrations. In addition, future pre-clinical and clinical studies to evaluate the safety and efficacy of GO–PVP–CUR–QSR for cancer treatment are strongly recommended.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Vinyl & Additive Technology

ISSN

1083-5601

e-ISSN

1548-0585

Volume of the periodical

30

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

1241-1253

UT code for WoS article

001220153000001

EID of the result in the Scopus database

2-s2.0-85192884537